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This distinction is critical for ethical and legal compliance

The 0.5mL option works if you have a high-quality syringe with clear markings at the 10-unit level, but cheaper syringes can make that small volume harder to measure accurately

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As of May 2025, New York regulations (10 NYCRR 80.63) require that providers conduct at least one in-person medical evaluation before prescribing any controlled substance to a patient (www.cchpca.org)

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Dr Mikhail Kosiborod, of Saint Lukes Mid America Heart Institute in Kansas City, was principal investigator on the study