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In cases where absorption is compromised, high oral doses or very high doses (such as 1,0002,000 mcg) of vitamin B12 may be required to correct deficiency, as these can sometimes be effective alternatives to injections

For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)

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Meanwhile, inflammation typically decreases with successful treatment

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For a deeper look at the synergy, see our guide on How to Take Vitamin C and Glutathione for Best Results