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VIP exerts its effects by binding to specific G-protein coupled receptors, notably VPAC1 and VPAC2 receptors, which are present in various tissues including the brain, gastrointestinal tract, and immune system (3)

Glutathione helps protect the skin from oxidative stress, reduces hyperpigmentation, and promotes a more even skin tone

These immunomodulatory and microbiome-sensitive strategies represent a paradigm shift moving from indiscriminate pathogen killing to restoring ecological balance and promoting healing

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There could also be residual confounding by the lingering effects of anti-diabetic medications such as metformin [30]

Lancet Phase 2 cagrilintide monotherapy trial (PMID 34480864) Enebo LB et al