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[53] The trials were conducted at 673 sites in 24 countries, including Argentina, Australia, Brazil, Canada, India, Israel, Japan, Mexico, Russian Federation, South Korea, Taiwan, European Union, and the United States (including Puerto Rico)
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By searching for biomarkers with potential therapeutic implications, the data provided evidence that high-power and high-endurance athletes have a distinct metabolic profile, including: steroid biosynthesis, fatty acid metabolism, oxidative stress, and energy-related metabolites
Berberine may also cause constipation and cramping, whilst L-carnitine can occasionally produce a fishy body odour or sleep disturbances