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Of note, this trial employed an individualized titration schedule on a variety of background regimens, which is likely more applicable to typical clinical practice

Over-the-counter options For headaches that do occur despite preventive measures, standard over-the-counter medications are generally safe and effective

Separate-vial workflow Three vials, two injection cadences Retatrutide is injected once a week

Patients may sometimes misinterpret the dosage of the medication, which can result in either underdosing, making the treatment ineffective, or overdosing, which can cause dangerous side effects

These social determinants of health create additional complexity in treatment implementation, particularly in underserved populations where obesity prevalence is often highest

Participants received weekly subcutaneous injections of retatrutide at one of four doses, or placebo, for 48 weeks