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Retatrutide has produced the largest weight loss reported in any Phase 3 obesity trial so far, but a UK launch is at least 18 months away

GLP-1 receptor agonists: weight loss as trigger, bioenergetics as outcome GLP-1 reduces appetite and weight, but the downstream cascade is bioenergetic, resulting in less ectopic fat (hepatic/visceral), reduced lipotoxicity, and relief of ER/mitochondrial stress across the liver, muscle, and heart

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Contact your GP for persistent diarrhoea beyond 7 days, severe constipation, or symptoms significantly impairing quality of life

Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review

Vikram M, Pande A, Vasudevan MC, Ravi R