It is highly selective for the growth hormone pathway , meaning it doesnt significantly stimulate cortisol, prolactin, or ghrelin a major issue with other peptides
doi:10.1152/physrev.00018.2018 4
doi: 10.3389/fendo.2022.1032199 Received 30 August 2022 Accepted 25 November 2022 Published 13 December 2022 Volume 13 - 2022 Edited by Sanbao Chai, Peking University, China Reviewed by Andrea Carranza, (CONICET), Argentina
10.1016/S2213-8587(20)30310-7 37 FeigD
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Women also face specific considerations around gallbladder disease risk, potential effects on bone density, and interactions with oral hormonal contraceptives