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Apesar da curta meia-vida plasmtica, os efeitos biolgicos downstream no tecido persistem substancialmente mais tempo, consistente com uma cascata de sinalizao e no com uma simples relao dose-resposta direta

N Engl J Med 349: 17381749

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Previously our group had shown that redox stress triggers gametocytogenesis in the malaria parasite

This might have been due to the resolution of nerve root edema and inflammatory reactions in both groups by the end of the follow-up