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SNRIs Duloxetine and venlafaxine have no known interactions with tirzepatide

These findings are biologically plausible, as both GLP1-RAs and SGLT2i exert pleiotropic effects beyond glycemic control, including improvements in endothelial function and reductions in systemic inflammation, which may counterbalance the prothrombotic milieu associated with type 2 diabetes

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Focus on timing with meals, hydration, and avoid eating heavy, fatty, and oily foods

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