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Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide

Indeed, this activity of the peptide was the first to be demonstrated, and it remained one of the most adequately described

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Today, AOD-9604 remains a topic of scientific interest, not as an approved therapy, but as a case study in how translational challenges can derail promising preclinical results

This material is intended for analytical and controlled research applications

& Rucman, R