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Additionally, CYP51A1 interacts with 15 core enzymes in the cholesterol biosynthesis pathway, including HMG-CoA reductase (HMGCR), FDFT1, dehydrocholesterol reductases (DHCRs), sigma non-opioid intracellular receptor 1 (SIGMAR1), and squalene epoxidase (SQLE), further supporting its central role in maintaining lipid homeostasis [47]
However, another researcher investigated the effects of caffeine and green coffee extract (GCE) on hepatic lipids in lean female rats with steatosis (Velzquez et al., 2020)
doi: 10.3390/ijms231910991
Cardiac damage in autoimmune diseases: target organ involvement that cannot be ignored
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