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These mechanisms range from hormone replacement and receptor modulation to direct antimicrobial activity, immune system regulation, and tissue repair processes

It is to underline that intellectual disabilities raise relevant ethical concerns in the bariatric treatment of adolescents with PWS and require an accurate preoperative analysis of psychological, social, and ethical aspects to adequately support patients and parents, and the long-term monitoring of the surgical outcome [109]

Melanocytes in the basal cell layer of the epithelium are connected to and communicate with their immediate neighbouring keratinocytes by means of tight junctions and gap junctions

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