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Weight Regain and Cardiometabolic Effects After Withdrawal of Semaglutide: The STEP 1 Trial Extension Diabetes, Obesity and Metabolism 24(8) 2022PMID: 35441470 PubMed 4 Drucker DJ Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 Cell Metabolism 27(4) 2018PMID: 29617641 PubMed 5 van Bloemendaal L, IJzerman RG, ten Kulve JS, et al
The probable pathway likely involves PCs augmenting GLUT4 translocation and glucose uptake in skeletal muscle through an AMPK-dependent mechanism, subsequently enhancing GLP-1activated insulin signaling and lowering postprandial hyperglycemia