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Weight-based dosing considerations While the standard clinical trial protocols use fixed-dose titration schedules regardless of body weight, some researchers adjust their approach based on body composition

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In the STEP trials for semaglutide and the SURMOUNT trials for tirzepatide, participants achieved substantial weight loss that far exceeded what most people accomplish through diet and exercise alone

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Furthermore, two studies revealed new molecular mechanisms for exendin-4 to affect MSC activities in myocardial infarction, which might present a hint for the same process in bone metabolism

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[] Stensen et al

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