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This vulnerability is partly explained by the fact that complexes I and III, both major ROS producers, contain subunits encoded by mtDNA, making them more susceptible to oxidative stress

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This action single-handedly reduces the cardiovascular stress and micro-clotting risks associated with elevated homocysteine

(2) molecular dynamics simulated annealing restraining FOXO4 FH (without flexible regions) harmonically to its template structure (using a non-crystallographic force constant of 10,000 kcal mol 1 2 ), with additional dihedral angle restraints from 1 H, 15 N, and 13 C chemical shifts using TALOS-N 56 , hydrogen bond restraints (region p53 residues 48-55

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4) [37,38,39,40,41,42,43,44,45,46,47,48], as treatment decision depends on the patients condition and the physicians opinion