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Consistently, we found that administration of CA, an endogenous FXR agonist, could not only significantly attenuate the T3-induced elevation of GLP-1 and insulin levels but also attenuate the glucose-lowering effect of T3 in MMI mice (Fig

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Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

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These results highlight how difficult it is for adolescents to keep weight off once they lose it. Those taking exenatide had an increase of 8 bpm in heart rate from randomization to 1 year compared with a 1 bpm increase for placebo ( P = .03)