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GLP-1 also increases pancreatic -cell proliferation by stimulating genes involved in cell proliferation and decreases the apoptosis of these cells by inhibiting caspase-3 expression

Phase II Clinical Data Jastreboff 2023 (NEJM) reported 24.2% bodyweight reduction at 48 weeks - the largest effect size published for any metabolic peptide in clinical trials

Recognising these patterns early helps you understand whether the change is linked to treatment

That patient probably needs to be monitored much more closely and to think much more deeply about whether or not a GLP-1 is right for them, he said

Continue your existing nodule surveillance schedule as recommended by your endocrinologist, regardless of tirzepatide use

Adequate fluid intake also helps combat fluid retention, constipation, and dehydration