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& Hochberg, Y

Enhanced insulin sensitivity through GLP-1 and GIP pathways improves glucose uptake in muscle tissue, supporting muscle protein synthesis and reducing proteolysis

Some gut bacteria synthesize vitamin K, which affects blood clotting

Oral formulations exist for both medications and may offer different tolerability profiles than injections

As of mid-2026, neither cagrilintide nor retatrutide is approved by the FDA or EMA for any indication

Prescribing of the compounds must be based upon the professional judgment of the licensed health care provider after considering the patients unique medical condition and factors including body weight, size and overall health status