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Then we have the ITT data

Patients were randomly assigned in a 2:1 ratio to receive vandetanib or placebo.[11][Level of evidence B1] With a median follow-up of 24 months, progression-free survival (PFS) favored vandetanib (hazard ratio [HR], 0.46

Limited long-term safety data further argue against routine use

It also i nteracts with multiple biologi cal pathways, providing cytoprotective, neuroprotective, and anti-inflammatory effects

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