Frondoside A downregulates Bcl-2 and survivin, increases ROS production, and promotes cytochrome c release, ultimately triggering mitochondrial apoptosis c release, ultimately triggering mitochondrial apoptosis (127)
One important caveat: wound serum from chronic wounds (such as diabetic ulcers) contains enzymes that break down GHK-Cu, which may limit topical efficacy on infected or chronic wounds
Lorente L, Martn MM, Gonzlez-Rivero AF, Prez-Cejas A, Cceres JJ, Perez A, Ramos-Gmez L, Sol-Violn J, Marcos y Ramos JA, Ojeda N, Jimnez A (2021) DNA and RNA oxidative damage and mortality of patients with COVID-19
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MiRNAs as hsa-miR-873-5p, hsa-miR-624-5p, hsa-miR-542-3p, and miR-338-3p, are critical regulators of essential ferroptosis-related genes
