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This hypercortisolism is also associated with reduction in the immune response [97]

In vitro , oral treatment of mangiferin at a dosage of 20 mg/kg improved insulin sensitivity in Streptozotocin-induced diabetic rats, altered lipid profiles, and reduced the amount of adipokine, and consequently, reduced the inflammation and metabolic syndrome development (Saleh et al., 2014)

Each of these options has strengths and weaknesses