Quick Answer: Millions of Americans currently use GLP-1 receptor agonists, with prescription rates showing substantial year-over-year growth as one of the fastest-expanding pharmaceutical classes in the United States
Phase II clinical trials published in Circulation showed SS-31 improved left ventricular function and exercise capacity in heart failure patients, with 28% improvement in 6-minute walk distance compared to placebo (Daubert et al., 2017)
Patterson CC, Karuranga S, Salpea P, et al
Follow-ups can be in-person or video, your choice (or your clinician's recommendation)
The 7.5% threshold used to be 10%, but legislative changes at the end of 2019 lowered it
Consistent with the potency gained from introducing the 6-carboxylic acid motif in the benzimidazole region, the cryo-EM structure showed that the carboxylic acid of PF-06883365 is making a productive interaction with an arginine residue at position 380 in the GLP-1R binding pocket