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Engineering of a femtomolar affinity binding protein to human serum albumin

10.1038/s41580-020-00317-7 16 CantiniG.MannucciE.LuconiM

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De Block CEM, Dirinck E, Verhaegen A, Van Gaal LF

It is even possible that the insulin-stimulating, glucagon-suppressing effects of the peptide or a more active synthetic analogue may be useful in the treatment of non-insulin-dependent diabetes, in which both impaired insulin release in response to glucose and persistent hyperglucagonemia are thought to be key pathophysiological abnormalities' (Kreymann, Ghattei, Williams, Bloom)

Although bone turnover markers CTX and P1NP declined, differences among groups were not statistically significant