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There is also a separate safety question, distinct from efficacy: retatrutide raises resting heart rate by 5 to 10 beats per minute, which has not yet been characterised in patients who already have heart failure or irregular heartbeats

As of the time of writing, retatrutide has not received marketing authorisation in the United Kingdom

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Typical Retatrutide Titration Schedule 1mg weekly 2mg weekly 4mg weekly 8mg weekly (if tolerated) 12mg weekly (maximum dose) Note: Slower escalation is acceptable if side effects are significant

Lilly's Zepbound (tirzepatide) superior to Wegovy (semaglutide) in head-to-head trial showing an average weight loss of 20.2% vs

A ResMed-supported study found that, after one year, there was no significant difference in CPAP adherence or discontinuation rates among recent GLP-1 users with OSA