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Sustained GHRH-receptor stimulation can blunt natural pulsatile GH release over time - the trade-off for DAC's convenience

Furthermore, pilot studies or studies in highly specialized populations (such as elite athletes) often have smaller sample sizes due to the difficulty of recruiting participants who meet the strict inclusion criteria

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As discussed above, unlike Y37 rAmy , P37 Cagri does not interact directly with RAMP1 or RAMP3, which likely decreases the stability of the ECD interface, leading to increased dynamics relative to the rAmy-bound AMY 1 R and rAmy-bound AMY 3 R (Fig