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Specifically, in a prospective cohort study, l-carnitine was associated with higher risk of prevalent coronary artery disease, peripheral artery disease, and overall CVD, possibly mediated by its intestinal metabolite, TMAO [5]
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3.2.2 Inflammatory signaling pathways such as nuclear factor kappa B (NF-B) or p38 mitogen-activated protein kinase (MAPK) Targeting upstream master regulators of inflammation, such as the NF-B and p38 MAPK pathways, offers a strategic therapeutic approach by potentially suppressing a broad spectrum of downstream pro-inflammatory effectors implicated in tinnitus pathogenesis
NOX is a membrane-bound enzyme complex that faces the extracellular space, and it can be found in the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms
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