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Dysbiosis under circadian misalignment impairs gut barrier function, alters bile acid pools, suppresses short-chain fatty acid (SCFA) production, and facilitates endotoxin translocationall of which aggravate liver inflammation and lipid accumulation via the gutliver axis

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Taken together, our results strongly suggest an effect of G49 in the recruitment of eosinophils and macrophages populations into eWAT, thereby promoting eosinophil-driven M2 polarization of macrophages

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