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(2008) Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis

In this model, iodine deficiency and Se deficiency exacerbate H2O2 accumulation, Se deficiency decreases cellular defense, promotes thyroid cell fibrosis, increases the inflammatory response following thyroid cell necrosis, and thiocyanate overload triggers follicular cell necrosis

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Glutathione is your body's master antioxidant and plays a critical role in protecting your thyroid gland from the oxidative damage caused by Hashimoto's autoimmune inflammation

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However, high dose sulforaphane (1700 mg/day) in a following study significantly improved some of the negative symptoms of schizophrenia after 24 weeks (Huang et al., 2025)