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Conclusions and perspectives Despite all the controversy in this space, the general consensus is that irAEs are not a pre-requisite for ICI benefit but rather a positive heralding sign of clinical benefit

The Repair and Regeneration Connection: GH and Tissue Healing GH/IGF-1 in Tissue Repair Growth hormone and IGF-1 play critical roles in tissue repair and regenerationconnecting GH secretagogues to cellular repair pathways

Efficacy was predicted by early response to treatment [115]

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