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In animal cells the fate of ITCs is well characterized: conjugation to glutathione by GSTs resulting in its intracellular depletion and subsequent degradation of dithiocarbamates through enzymatic events catalysed by -glutamyltranspeptidase, cysteinylglycinase and N -acetyltransferase via the mercapturic acid pathway 76

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In bacteria, the theta class GSTs includes all of the currently known bacterial glutathione transferases

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R., Mooney, S., Zarif, J

A meta-analysis investigating the association between GSTs and coronary heart disease, stratified by smoking status, also unveiled an elevated risk among individuals with null genotypes compared with those with non-null genotypes