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GLP-1 MODULATES LIPID METABOLISM GLP-1 Modulates fat synthesis in the liver GLP-1 modulates hepatic lipolysis GLP-1 modulates liver cholesterol metabolism GLP-1 modulates adiposynthetic and differentiation GLP-1 modulates fat browning Clinical application of GLP-1 in obesity Obesity is a major health problem worldwide

Metabolism Open

The Novo Nordisk Foundation Center for Protein Research is supported financially by the Novo Nordisk Foundation (grant number NNF14CC0001)

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Approved by the FDA in October 2006, and branded as Januvia, the drug soon became one of Merck's most successful drugs

If interventions are not started, the increased demand for insulin can overload pancreatic -cells leading to pancreatic -cell failure, decreased insulin secretion, and uncontrolled glycemia (Figure 1)