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At week 13, significant, dose-dependent reductions in HbA 1c (the primary endpoint) were reported [10]

[9] [25] Patients should be alert to symptoms such as right upper quadrant pain, fever, or jaundice, which warrant urgent medical attention

However, as gallbladder disease is not an issue with sodium-glucose co-transporter-2 (SGLT-2) inhibitors (with similar weight loss) (89), and gallbladder events also occurred in GLP-1RA-treated patients well after weight reduction (90), other mechanisms are possibly in play

Symptoms suggesting urinary tract infection Burning sensation during urination, urgent need to urinate, lower abdominal pain, fever, or blood in urine

EHR=electronic health record