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Common examples include semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity)

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The rationale for including glucagon receptor agonism is the mechanistically interesting part: glucagon signalling raises hepatic energy expenditure and promotes lipolysis but also raises circulating glucose on its own, so the two incretin arms are there to counterbalance that consequence while the thermogenic effect proceeds

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People with diabetes may have A1C checked more frequently after a treatment change or when goals are not being met and less often when results and treatment are stable

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