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Both formulations support hepatic fat metabolism by providing methyl donors that facilitate the conversion of fat into bile acids for elimination

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It is most likely that the CV benefits observed in EMPA REG OUTCOME were related to the hemodynamic benefits of the drug including simultaneous: (i) preload reduction (due to increased salt/water excretion and intravascular volume depletion), (ii) postload reduction (due to decrease in blood pressure), and (iii) decreased aortic stiffness (45)

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4.3 Growth differentiation factor 15 Growth differentiation factor 15 is emerging as a biomarker involved in inflammation, cellular stress responses, and energy metabolism