Upon stimulation, patatin-like phospholipase domain containing 2 (PNPLA2)/adipocyte triglyceride lipase (ATGL), the rate limiting enzyme for TAG hydrolysis, is activated by the interaction with its co-activator, alpha/beta hydrolase domain-containing protein 5 (ABHD5), which is normally bound to perilipin 1 (PLIN1)
As endogenous danger signals, damage-associated molecular pattern molecules (DAMPs) enable macrophage recruitment and activation, alerting the immune system
Together, these steps defined the -cell-enriched expression filter
Selenium deficiency induces duodenal villi cell apoptosis via an oxidative stress-induced mitochondrial apoptosis pathway and an inflammatory signaling-induced death receptor pathway
Logan JK, Tang C, Liao Z, Lee JJ, Heymach JV, Swisher SG , Welsh JW, Zhang J, Lin SH, Gomez DR
doi:10.1051/0004-6361/202142600