what happens when you stop taking glp-1 medication Here's Weight Loss Drugs What happens after stopping GLP-1

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doi: 10.3389/fendo.2019.00155 96 ChristouGAKatsikiNBlundellJFruhbeckGKiortsisDN

The closed conformation of the inactive GLP-1R results in partial solvent protection of the hydrophobic ECD binding site, which is considered energetically favorable for an apo-state compared to an open conformation with full solvent exposure of the binding site

The theory is that smaller, more frequent doses maintain receptor stimulation at a level that avoids heavy desensitization while preserving beneficial effects

Notably, GLP-1RAs slow the transit time of the gastrointestinal (GI) tract and suppress appetite, which could displace nutrient intake and result in mineral and vitamin deficiencies

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