Retatrutide is a triple receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, whereas semaglutide activates only the GLP-1 receptor and tirzepatide activates GLP-1 and GIP receptors
Egypt J Neurol, Psychiatry Neurosurg
In pancreatic cells, proglucagon is cleaved to produce glucagon, glicentin-related pancreatic polypeptide (GRPP), intervening peptide-1 (IP-1), and the major proglucagon fragment (MPGF), constituting GLP-1, IP-2, and GLP-2
Activation of cardiac GLP-1 receptors appears to provide direct cardioprotective effects including improved cardiac function and reduced inflammation in heart tissue
Organic Cinnamon Ceylon Extract (Cinnamomum verum)
For older adults (aged 65 years), the WHO recommends varied multicomponent physical activity, with a focus on balance and strength training, of at least moderate intensity on three or more days each week [115]