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In comparison, phenformin showed much less impairment of cell growth with a CC 50 of 2060 M in Calu-3 and 1313 M in Huh7.5 cells (Fig

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Among those 22 protein complexes, we selected four, encompassing 11 of the 39 enzyme targets, for further experimental validation based upon additional criteria such as evidence from CRISPR-Cas9 screens 32,33,34 , relevance in other viral diseases, and the availability of inhibitors, as discussed below

Nadph oxidases and angiotensin ii receptor signaling

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