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When secreted by L cells, GLP-1 either functions in an endocrine manner, being released into the blood stream where it is rapidly inactivated by DPP-4 with a half-life of about 2 min, or exerts paracrine effects like stimulating neurons

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Key Research Findings & Benefits Unprecedented Weight Loss Data: Clinical trials have demonstrated mean weight reductions of up to 24.2%, approaching bariatric surgery outcomes

The hazard ratio and 95% confidence interval did not reveal a significant difference between tirzepatide or insulin glargine treatment (HR, 0.74

SGLT2 inhibitors also have a modest effect to lower blood pressure