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The mean BMI was 33.9 kg/m2 and the mean BMI SDS was 2.9

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A final approach to glycaemic management when basal insulin plus oral medications is insufficient to achieve HbA 1c targets is intensified insulin regimens (Figs 7 and 8)

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In patients with pre-existing severe gastrointestinal dysmotility, such as gastroparesis, this effect may worsen symptoms significantly