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It doesnt enter systemic circulation
That means the risk of acquiring contact sensitivty is quite low
Response to certolizumab pegol in the RAPID-PsA trial was comparable to other TNF inhibitors in PsA, with 58% of the certolizumab pegol 200 mg every-2-weeks group and 51.9% of the certolizumab pegol 400 mg every-4-weeks group achieving an ACR20 at 12 weeks compared with 24.3% in the placebo arm (Figure 7-16)
Free Radic Biol Med (2018) 127:1604
After receiving a 1 mg dose of autologous menstrual blood-derived MSC exosomes intrauterine 48 hours before embryo transfer, she achieved a successful pregnancy and live birth
PMCID: PMC9616098
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