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In order to enhance the applicability of this in vitro model, the effect of shear stress could be combined with other relevant triggers, such as hyperglycemia

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References: Rosenwasser AM et al

The approaches work through different mechanisms and tissue concentrations

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Neither the disulfide lipoic acid (LA) nor GSSSG worked in this manner, and thus served as reliable controls in the high-dose experiments (Figure 1e bars 47 and Figure 2c,d)