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In regards to the insulin signaling pathway, high concentrations of H 2 O 2 /O inhibit insulin receptor substrates and the PI3K/AKT pathway through oxidative stress, leading to the development of insulin resistance [179, 180]

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To further explore this effect, we examined additional GGT inhibitors (acivicin and OU749) 45 but found that GGsTop was the most potent at blocking GGT activity (Fig

In rare cases, hospitalization might be needed for proper treatment and monitoring