Nature 400 , 576581 (1999)
Miller BC, Sen DR, Abosy RA, Bi K, Virkud YV, LaFleur MW, et al
Update 29, 395433
Therefore, the precise mechanisms through which lipoxygenases contribute to ferroptosis, particularly in GPX4 inhibition contexts, require further investigation ( 3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA
This is why its recommended as a potential treatment for different disorders resulting from free oxygen radicals, such as liver disease, Alzheimers, Parkinsons and even cancer
None of us can survive without it