In terms of Type 2 diabetes, which accounts for over 90% of adult cases of diabetes, some people are more susceptible due to inherited risk
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Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing
In three phase 2 clinical ocular trials during which patients self-administered 0.1% T4 eye drops 2 to 6 times per day for 28 days reported no evidence of any adverse events
That said, collaboration is wise: communicate with the patients PCP, dont usurp necessary medical workups (rule out endocrine causes, get baseline labs), and refer to specialists (endocrinology, cardiology) when appropriate
In particular, information on the genotype-phenotype characterization of MertS and its characteristics is fragmented