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Currently, several checkpoint inhibitors are approved by the US Food and Drug Administration, including cytotoxic T-lymphocyteassociated antigen 4 (CTLA-4) inhibitors and programmed cell death 1 (PD-1) or PD ligand 1 (PD-L1) inhibitors

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PMID 22995213

All fascicles in each nerve showed increased diameter of myelinated fibers, thickness of myelin sheet, number of myelinated fibers per area and myelinated fibers as a percentage of the nerve transected area and the increased blood vessels presentation