While the gastric emptying function of incretin mimetics may facilitate weight loss, it may have gastrointestinal effects and also impact the action of other medications taken orally
They delay gastric emptying as to decrease the physical feeling of needing to eat and they target the brains dopamine reward pathways which can dull the reward of highly desired foods
Swain RS, Taylor LG, Braver ER, Liu W, Pinheiro SP, Mosholder AD (2019) A systematic review of validated suicide outcome classification in observational studies
Gradual dose escalation as used in the clinical trials appeared to help reduce the burden of these side effects
Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus
It's why prescription GLP-1 medications like Wegovy and Mounjaro are injected the molecules are too large and active at too high a dose to deliver any other way (with the exception of Rybelsus, which uses sophisticated absorption enhancers to make oral semaglutide work)
