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Rare heterozygous loss-of-function variants in the human GLP-1 receptor do not associate with cardiometabolic phenotypes

Medical Weight Loss with GLP-1s: What They Are, How They Work, and Whether Theyre Right for You GLP-1 medications such as semaglutide and tirzepatide have become some of the most talked-about tools in medical weight loss and metabolic health

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3 But the effects of GLP-1 RAs are even more sweeping

A large cardiovascular outcomes trial found that higher proportions of tirzepatide recipients reported vomiting, diarrhea, and nausea compared to those taking a selective GLP-1RA