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Additionally, hyperinsulinemia induces a pro-contractile phenotype in airway smooth muscle (ASM) cells and increases their sensitivity to neural-mediated bronchoconstriction [48,49,50]

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Emerging evidence reported the role of glutamine mediating reductive carboxylation for lipid biosynthesis and also for redox homeostasis in cancer with dysfunctional mitochondria or under hypoxia [34,41-43]

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