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Navone, N

some head-to-head data suggest slightly higher GI events with Tirzepatide , but discontinuation rates remain modest with slow escalation

Tirzepatide is currently in Phase III development for adults with obesity or overweight who have weight-related comorbidity, and the FDA is also reviewing it as a treatment for adults with type 2 diabetes

Outside those trials, it does not legitimately exist

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This might hint at an advantage over 'unbiased' GLP-1 receptor agonists by potentially addressing the issue of insulin resistance, which is a significant concern for overweight or obese individuals